All substances for selected list or group
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Results for list or group "Living Organisms on the Domestic Substances List"
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| List or group: | Living Organisms on the Domestic Substances List |
| Substance identifier: | |
| Substance identifier (2): | |
| Substance name: | Human adenovirus serotype 26, E1/E3 deleted, E4orf6 substituted human adenovirus serotype 5 E4orf6, encoding Respiratory syncytial virus (RSV) F protein stabilized in the prefusion conformation (pref) (Ad26.RSV.pref) |
| Additional information: | This substance is a living organism. |
| Recent publication(s): | Canada Gazette Part II, Vol. 153, No. 12, June 12 2019, SOR/2019-159 |
| Date published: | 2019-06-12 |
| Substance identifier: | |
| Substance identifier (2): | |
| Substance name: | Human allogeneic CAR T cells targeting CD70 and genetically modified by CRISPR/Cas9 disrupting the T cell receptor alpha constant (TRAC), β2-microglobulin (B2M), and CD70 loci; and by a CAR gene–containing recombinant adeno-associated virus (AAV) vector inserting the anti-CD70 CAR expression cassette into the TRAC locus (CTX130) |
| Additional information: | This substance is a living organism. |
| Recent publication(s): | Canada Gazette Part II, Vol. 155, No. 11, May 26, 2021, SOR/2021-98 |
| Date published: | 2021-05-26 |
| Substance identifier: | |
| Substance identifier (2): | |
| Substance name: | Human allogeneic CAR T cells targeting the B cell maturation antigen (BCMA) and genetically modified by CRISPR/Cas9 disrupting the T cell receptor alpha constant (TRAC) and β2-microglobulin (B2M) loci and by a CAR gene–containing recombinant adeno-associated virus (AAV) vector inserting the anti-BCMA CAR expression cassette into the TRAC locus |
| Additional information: | This substance is a living organism. |
| Recent publication(s): | Canada Gazette Part II, Vol. 158, No. 20, September 25 2024, SOR/2024-173 |
| Date published: | 2024-09-25 |
| Substance identifier: | |
| Substance identifier (2): | |
| Substance name: | Human autologous CD34+ hematopoietic cells genetically modified by the CRISPR-Cas9 and guide RNA, disrupting the erythroid enhancer region of the B-Cell Lymphoma/Leukemia 11A (BCL11A) gene on chromosome 2 |
| Additional information: | This substance is a living organism. |
| Recent publication(s): | Canada Gazette Part II, Vol. 154, No. 6, March 18, 2020, SOR/2020-36 |
| Date published: | 2020-03-18 |
| Substance identifier: | 19614-2 |
| Substance identifier (2): | |
| Substance name: | Human autologous T lymphocyte expressing a chimeric antigen receptor for human B cell maturation antigen ’1’ |
| Additional information: | This substance is a living organism. |
| Recent publication(s): | Canada Gazette Part II, Vol. 156, No. 22, October 26, 2022, SOR/2022-207 |
| Date published: | 2022-10-26 |
| Substance identifier: | |
| Substance identifier (2): | |
| Substance name: | Human autologous T lymphocytes transduced with a replication incompetent recombinant lentiviral vector carrying a CLDN18.2-directed receptor gene (CT041) |
| Additional information: | This substance is a living organism. |
| Recent publication(s): | Canada Gazette Part II, Vol. 158, No. 15, July 17, 2024, SOR/2024-159 |
| Date published: | 2024-07-17 |
| Substance identifier: | |
| Substance identifier (2): | |
| Substance name: | Human autologous T lymphocytes transduced with a retroviral vector (PG13-CD19-H3) containing anti-CD19/CD28/CD3zeta chimeric antigen receptor targeting CD19 on the cell surface of B cells |
| Additional information: | This substance is a living organism. |
| Recent publication(s): | Canada Gazette Part II, Vol. 154, No. 6, March 18 2020, SOR/2020-42 |
| Date published: | 2020-03-18 |
| Substance identifier: | |
| Substance identifier (2): | |
| Substance name: | Human CD34+ hematopoietic stem cells prime edited ex vivo to correct delGT genetic mutations on the NCF1 gene (PM359) |
| Additional information: | This substance is a living organism. |
| Recent publication(s): | Canada Gazette Part II, Vol. 159, No. 19, September 10, 2025, SOR/2025-173 |
| Date published: | 2025-09-10 |
| Substance identifier: | |
| Substance identifier (2): | |
| Substance name: | Human oncolytic Vaccinia virus Copenhagen strain with deletions in the 5 prime and 3 prime regions of the genome and B8R locus disruption, expressing anti-CTLA-4 antibody, FLT-3 ligand and membrane bound IL-12 (p35 subunit) (TBio-6517) |
| Additional information: | This substance is a living organism. The Public Health Agency of Canada (PHAC) has classified this biological agent as a human and/or terrestrial animal pathogen. Under the Human Pathogens and Toxins Act (HPTA), controlled activities with human pathogens that are classified as Risk Group 2-4 require a licence, issued by PHAC. PHAC is also responsible for issuing permits for the importation of pure cultures of terrestrial animal pathogens of Risk Group 2-4, with the exception of non-indigenous animal pathogens and pathogens causing emerging animal disease, under the authority of the Health of Animal Regulations (HAR). For a listing of Risk Group classifications of biological agents in Canada, visit ePATHogen - Risk Group Database. Please contact pathogens.pathogenes@phac-aspc.gc.ca for further information. Please note: The Canadian Food Inspection Agency (CFIA) has the authority under the Health of Animals Act and the Health of Animals Regulations to issue importation permits for animals, animal products and by-products, aquatic animal pathogens, bee pathogens, pathogens causing foreign animal diseases, and pathogens causing emerging animal diseases. The CFIA also issues import permits for plant pests under the Plant Protection Act. |
| Recent publication(s): | Canada Gazette Part II, Vol. 155, No. 5, March 3, 2021, SOR/2021-16 |
| Date published: | 2021-03-03 |
| Substance identifier: | |
| Substance identifier (2): | |
| Substance name: | Human peripheral blood mononuclear cells presenting HLA-A-02 restricted E6 and E7 epitopes of the human papillomavirus 16 (SQZ-PBMC-HPV) |
| Additional information: | This substance is a living organism. |
| Recent publication(s): | Canada Gazette Part II, Vol. 156, No. 1, January 5 2022, SOR/2021-261 |
| Date published: | 2022-01-05 |
| Substance identifier: | |
| Substance identifier (2): | |
| Substance name: | Human T lymphocytes modified with a lentiviral vector encoding a chimeric antigen receptor directed to CD19 antigen (ACT-C01) |
| Additional information: | This substance is a living organism. |
| Recent publication(s): | Canada Gazette Part II, Vol. 155, No. 14, July 7, 2021, SOR/2021-159 |
| Date published: | 2021-07-07 |
| Substance identifier: | |
| Substance identifier (2): | |
| Substance name: | Human T lymphocytes stimulated with synthetic peptides specific for adenovirus, BK virus, cytomegalovirus, Epstein-Barr virus, and human herpesvirus-6 (posoleucel) |
| Additional information: | This substance is a living organism. |
| Recent publication(s): | Canada Gazette Part II, Vol. 157, No. 14, July 5 2023, SOR/2023-145 |
| Date published: | 2023-07-05 |
| Substance identifier: | |
| Substance identifier (2): | |
| Substance name: | Human T lymphocytes transduced with a lentiviral vector pseudotyped with the vesicular stomatitis virus glycoprotein envelope, encoding the chimeric antigen receptor (CAR) targeting the human B cell CD19 antigen expressed under the control of the human elongation factor 1 α (EF-1α) promoter |
| Additional information: | This substance is a living organism. |
| Recent publication(s): | Canada Gazette Part II, Vol. 157, No. 11, May 24 2023, SOR/2023-90 |
| Date published: | 2023-05-24 |
| Substance identifier: | 19702-0 |
| Substance identifier (2): | |
| Substance name: | Human T lymphocytes transduced with a replication-incompetent lentiviral vector pseudotyped with the vesicular stomatitis virus glycoprotein envelope, encoding the chimeric antigen receptor (CAR) targeting the human B cell surface antigen expressed under the control of the human elongation factor 1 α (EF-1α) promoter (CLIC-1901) |
| Additional information: | This substance is a living organism. |
| Recent publication(s): | Canada Gazette Part II, Vol. 158, No. 11, May 22, 2024, SOR/2024-83 |
| Date published: | 2024-05-22 |
| Substance identifier: | 19477-5 |
| Substance identifier (2): | |
| Substance name: | Human T lymphocytes transduced with a self-inactivating lentiviral vector, encoding an affinity optimized T cell receptor targeting the NY-ES0-1/LAGE-1a antigen |
| Additional information: | This substance is a living organism. |
| Recent publication(s): | Canada Gazette Part II, Vol. 154, No. 20, September 30, 2020, SOR/2020-204 |
| Date published: | 2020-09-30 |
| Substance identifier: | 19786-4 |
| Substance identifier (2): | |
| Substance name: | Human T-cells transduced with a replication-deficient lentiviral vector encoding a chimeric antigen receptor targeting a human B-cell surface antigen (CLIC-2201) |
| Additional information: | This substance is a living organism. |
| Recent publication(s): | Canada Gazette Part II, Vol. 159, No. 19, September 10, 2025, SOR/2025-173 |
| Date published: | 2025-09-10 |
| Substance identifier: | |
| Substance identifier (2): | |
| Substance name: | KB-1® Anaerobic Dechlorinating consortium containing Dehalococcoides spp. |
| Additional information: | This substance is a living organism. |
| Recent publication(s): | Canada Gazette Part II, Vol. 142, No. 17, August 20 2008, SOR/2008-242 |
| Date published: | 2008-08-20 |
| Substance identifier: | |
| Substance identifier (2): | |
| Substance name: | Lactococcus lactis subsp. cremoris strain sAGX0037 |
| Additional information: | This substance is a living organism. |
| Recent publication(s): | Canada Gazette Part II, Vol. 143, No. 5, March 04 2009, SOR/2009-39 |
| Date published: | 2009-03-04 |
| Substance identifier: | ATCC 4698 |
| Substance identifier (2): | |
| Substance name: | Micrococcus luteus |
| Additional information: | This substance is a living organism. |
| Recent publication(s): | Canada Gazette Part II, April 30, 1997, SOR/97-197 |
| Date published: | 1997-04-30 |
| Substance identifier: | |
| Substance identifier (2): | |
| Substance name: | MicroRNA attenuated oncolytic HSV-1 recombinantly expressing IL-12, CCL4, FLT3L and antagonists of CTLA-4 and PD-1 (ONCR-177) |
| Additional information: | This substance is a living organism. |
| Recent publication(s): | Canada Gazette Part II, Vol. 156, No. 1, January 5 2022, SOR/2021-261 |
| Date published: | 2022-01-05 |
| Substance identifier: | 19745-3 |
| Substance identifier (2): | |
| Substance name: | Modified human T-cells expressing a GPRC5D-directed chimeric antigen receptor |
| Additional information: | This substance is a living organism. |
| Recent publication(s): | Canada Gazette Part II, Vol. 158, No. 26, December 18 2024, SOR/2024-252 |
| Date published: | 2024-12-18 |
| Substance identifier: | 16969-4 |
| Substance identifier (2): | |
| Substance name: | Nitrobacter species |
| Additional information: | This substance is a living organism. |
| Recent publication(s): | Canada Gazette Part II, Vol. 138, No. 18, September 08 2004, SOR/2004-184 |
| Date published: | 2004-09-08 |
| Substance identifier: | ATCC 25391 |
| Substance identifier (2): | |
| Substance name: | Nitrobacter winogradskyi |
| Additional information: | This substance is a living organism. |
| Recent publication(s): | Canada Gazette Part II, Vol. 139, No. 18, September 07 2005, SOR/2005-236 |
| Date published: | 2005-09-07 |
| Substance identifier: | 16972-7 |
| Substance identifier (2): | |
| Substance name: | Nitrococcus species |
| Additional information: | This substance is a living organism. |
| Recent publication(s): | Canada Gazette Part II, Vol. 138, No. 18, September 08 2004, SOR/2004-184 |
| Date published: | 2004-09-08 |
| Substance identifier: | 16971-6 |
| Substance identifier (2): | |
| Substance name: | Nitrosococcus species |
| Additional information: | This substance is a living organism. |
| Recent publication(s): | Canada Gazette Part II, Vol. 138, No. 18, September 08 2004, SOR/2004-184 |
| Date published: | 2004-09-08 |
| Substance identifier: | ATCC 25978 |
| Substance identifier (2): | |
| Substance name: | Nitrosomonas europaea |
| Additional information: | This substance is a living organism. |
| Recent publication(s): | Canada Gazette Part II, Vol. 139, No. 18, September 07 2005, SOR/2005-236 |
| Date published: | 2005-09-07 |
| Substance identifier: | 16968-3 |
| Substance identifier (2): | |
| Substance name: | Nitrosomonas species |
| Additional information: | This substance is a living organism. |
| Recent publication(s): | Canada Gazette Part II, Vol. 138, No. 18, September 08 2004, SOR/2004-184 |
| Date published: | 2004-09-08 |
| Substance identifier: | |
| Substance identifier (2): | |
| Substance name: | Non-genetically modified human lymphocytes |
| Additional information: | This substance is a living organism. |
| Recent publication(s): | Canada Gazette Part II, Vol. 154, No. 26, December 23, 2020, SOR/2020-270 |
| Date published: | 2020-12-23 |
| Substance identifier: | |
| Substance identifier (2): | |
| Substance name: | Non-replicating recombinant adeno-associated virus containing AAV9 capsid and a codon-optimized expression cassette encoding OptiDysΔ3978 (mini-dystrophin) (PF-06939926) |
| Additional information: | This substance is a living organism. |
| Recent publication(s): | Canada Gazette Part II, Vol. 156, No. 1, January 5 2022, SOR/2021-264 |
| Date published: | 2022-01-05 |
| Substance identifier: | |
| Substance identifier (2): | |
| Substance name: | Non-replicating recombinant adeno-associated virus PF-06838435 containing AAV-Spark100 capsid and encoding a codon-optimized human coagulation Factor IX variant with a high specific activity |
| Additional information: | This substance is a living organism. |
| Recent publication(s): | Canada Gazette Part II, Vol. 154, No. 14, July 8 2020, SOR/2020-137 |
| Date published: | 2020-07-08 |
| Substance identifier: | |
| Substance identifier (2): | |
| Substance name: | Non-replicating self-complementary human adeno-associated virus vector containing a codon-optimized human ornithine transcarbamylase gene expression cassette flanked by adeno-associated virus serotype 2 inverted terminal repeat sequences packaged in a human adeno-associated virus serotype 8 capsid N |
| Additional information: | This substance is a living organism. |
| Recent publication(s): | Canada Gazette Part II, Vol. 153, No. 13, June 26 2019, SOR/2019-209 |
| Date published: | 2019-06-26 |
| Substance identifier: | |
| Substance identifier (2): | |
| Substance name: | Non-replicating, recombinant human adeno-associated virus (AAV) serotype 8 vector containing a codon-optimized version of the wild-type human glucose-6-phosphatase-α coding sequence under the control of its native promoter/enhancer and followed by the late poly A from SV40 and flanked by wild-type AAV serotype 2 inverted terminal repeat (ITR) sequences |
| Additional information: | This substance is a living organism. |
| Recent publication(s): | Canada Gazette Part II, Vol. 154, No. 6, March 18 2020, SOR/2020-42 |
| Date published: | 2020-03-18 |
| Substance identifier: | ATCC 55407 |
| Substance identifier (2): | |
| Substance name: | Paenibacillus polymyxa |
| Additional information: | This substance is a living organism. |
| Recent publication(s): | Canada Gazette Part II, April 30, 1997, SOR/97-197 |
| Date published: | 1997-04-30 |
| Substance identifier: | ATCC 842 |
| Substance identifier (2): | |
| Substance name: | Paenibacillus polymyxa |
| Additional information: | This substance is a living organism. |
| Recent publication(s): | Canada Gazette Part II, April 30, 1997, SOR/97-197 |
| Date published: | 1997-04-30 |
| Substance identifier: | 13540-4 |
| Substance identifier (2): | |
| Substance name: | Peanibacillus polymyxa strain |
| Additional information: | This substance is a living organism. |
| Recent publication(s): | Canada Gazette Part II, Vol. 132, No. 13, June 24 1998, SOR/98-335 |
| Date published: | 1998-06-24 |
| Substance identifier: | |
| Substance identifier (2): | |
| Substance name: | Phlebiopsis gigantea strain FTK 897A |
| Additional information: | This substance is a living organism. |
| Recent publication(s): | Canada Gazette Part II, Vol. 147, No. 21, October 09 2013, SOR/2013-170 |
| Date published: | 2013-10-09 |
| Substance identifier: | |
| Substance identifier (2): | |
| Substance name: | Prevotella histicola strain ES894 |
| Additional information: | This substance is a living organism. |
| Recent publication(s): | Canada Gazette Part II, Vol. 156, No. 17, August 17 2022, SOR/2022-181 |
| Date published: | 2022-08-17 |
| Substance identifier: | ATCC 700371 |
| Substance identifier (2): | |
| Substance name: | Pseudomonas aeruginosa |
| Additional information: | This substance is a living organism. The Public Health Agency of Canada (PHAC) has classified this biological agent as a human and/or terrestrial animal pathogen. Under the Human Pathogens and Toxins Act (HPTA), controlled activities with human pathogens that are classified as Risk Group 2-4 require a licence, issued by PHAC. PHAC is also responsible for issuing permits for the importation of pure cultures of terrestrial animal pathogens of Risk Group 2-4, with the exception of non-indigenous animal pathogens and pathogens causing emerging animal disease, under the authority of the Health of Animal Regulations (HAR). For a listing of Risk Group classifications of biological agents in Canada, visit ePATHogen - Risk Group Database. Please contact pathogens.pathogenes@phac-aspc.gc.ca for further information. Please note: The Canadian Food Inspection Agency (CFIA) has the authority under the Health of Animals Act and the Health of Animals Regulations to issue importation permits for animals, animal products and by-products, aquatic animal pathogens, bee pathogens, pathogens causing foreign animal diseases, and pathogens causing emerging animal diseases. The CFIA also issues import permits for plant pests under the Plant Protection Act. |
| Recent publication(s): | Canada Gazette Part II, Vol. 158, No. 15, July 17 2024, SOR/2024-159 |
| Date published: | 2024-07-17 |
| Substance identifier: | ATCC 31480 |
| Substance identifier (2): | |
| Substance name: | Pseudomonas aeruginosa |
| Additional information: | This substance is a living organism. The Public Health Agency of Canada (PHAC) has classified this biological agent as a human and/or terrestrial animal pathogen. Under the Human Pathogens and Toxins Act (HPTA), controlled activities with human pathogens that are classified as Risk Group 2-4 require a licence, issued by PHAC. PHAC is also responsible for issuing permits for the importation of pure cultures of terrestrial animal pathogens of Risk Group 2-4, with the exception of non-indigenous animal pathogens and pathogens causing emerging animal disease, under the authority of the Health of Animal Regulations (HAR). For a listing of Risk Group classifications of biological agents in Canada, visit ePATHogen - Risk Group Database. Please contact pathogens.pathogenes@phac-aspc.gc.ca for further information. Please note: The Canadian Food Inspection Agency (CFIA) has the authority under the Health of Animals Act and the Health of Animals Regulations to issue importation permits for animals, animal products and by-products, aquatic animal pathogens, bee pathogens, pathogens causing foreign animal diseases, and pathogens causing emerging animal diseases. The CFIA also issues import permits for plant pests under the Plant Protection Act. |
| Recent publication(s): | Canada Gazette Part II, Vol. 158, No. 15, July 17 2024, SOR/2024-159 |
| Date published: | 2024-07-17 |
| Substance identifier: | ATCC 700370 |
| Substance identifier (2): | |
| Substance name: | Pseudomonas aeruginosa |
| Additional information: | This substance is a living organism. The Public Health Agency of Canada (PHAC) has classified this biological agent as a human and/or terrestrial animal pathogen. Under the Human Pathogens and Toxins Act (HPTA), controlled activities with human pathogens that are classified as Risk Group 2-4 require a licence, issued by PHAC. PHAC is also responsible for issuing permits for the importation of pure cultures of terrestrial animal pathogens of Risk Group 2-4, with the exception of non-indigenous animal pathogens and pathogens causing emerging animal disease, under the authority of the Health of Animal Regulations (HAR). For a listing of Risk Group classifications of biological agents in Canada, visit ePATHogen - Risk Group Database. Please contact pathogens.pathogenes@phac-aspc.gc.ca for further information. Please note: The Canadian Food Inspection Agency (CFIA) has the authority under the Health of Animals Act and the Health of Animals Regulations to issue importation permits for animals, animal products and by-products, aquatic animal pathogens, bee pathogens, pathogens causing foreign animal diseases, and pathogens causing emerging animal diseases. The CFIA also issues import permits for plant pests under the Plant Protection Act. |
| Recent publication(s): | Canada Gazette Part II, Vol. 158, No. 15, July 17 2024, SOR/2024-159 |
| Date published: | 2024-07-17 |
| Substance identifier: | ATCC 13525 |
| Substance identifier (2): | |
| Substance name: | Pseudomonas fluorescens |
| Additional information: | This substance is a living organism. |
| Recent publication(s): | Canada Gazette Part II, Vol. 150, No. 14, July 13 2016, SOR/2016-159 |
| Date published: | 2016-07-13 |
| Substance identifier: | ATCC 12633 |
| Substance identifier (2): | |
| Substance name: | Pseudomonas putida |
| Additional information: | This substance is a living organism. |
| Recent publication(s): | Canada Gazette, Part II, Vol. 152, No. 11, May 30 2018, SOR/2018-96 |
| Date published: | 2018-05-30 |
| Substance identifier: | ATCC 700369 |
| Substance identifier (2): | |
| Substance name: | Pseudomonas putida |
| Additional information: | This substance is a living organism. |
| Recent publication(s): | Canada Gazette, Part II, Vol. 152, No. 11, May 30 2018, SOR/2018-96 |
| Date published: | 2018-05-30 |
| Substance identifier: | ATCC 31483 |
| Substance identifier (2): | |
| Substance name: | Pseudomonas putida |
| Additional information: | This substance is a living organism. |
| Recent publication(s): | Canada Gazette, Part II, Vol. 152, No. 11, May 30 2018, SOR/2018-96 |
| Date published: | 2018-05-30 |
| Substance identifier: | ATCC 31800 |
| Substance identifier (2): | |
| Substance name: | Pseudomonas putida |
| Additional information: | This substance is a living organism. |
| Recent publication(s): | Canada Gazette, Part II, Vol. 152, No. 11, May 30 2018, SOR/2018-96 |
| Date published: | 2018-05-30 |
| Substance identifier: | ATCC 13867 |
| Substance identifier (2): | |
| Substance name: | Pseudomonas sp. |
| Additional information: | This substance is a living organism. |
| Recent publication(s): | Canada Gazette Part II, Vol. 139, No. 18, September 07 2005, SOR/2005-236 |
| Date published: | 2005-09-07 |
| Substance identifier: | ATCC 17587 |
| Substance identifier (2): | |
| Substance name: | Pseudomonas stutzeri |
| Additional information: | This substance is a living organism. |
| Recent publication(s): | Canada Gazette Part II, Vol. 139, No. 18, September 07 2005, SOR/2005-236 |
| Date published: | 2005-09-07 |
| Substance identifier: | |
| Substance identifier (2): | |
| Substance name: | Recombinant adeno-associated virus (AAV) containing AAV-LK03 capsid (AAV-Spark200) and encoding the SQ variant of B-domain deleted human factor VIII |
| Additional information: | This substance is a living organism. |
| Recent publication(s): | Canada Gazette Part II, Vol. 157, No. 7, March 29 2023, SOR/2023-50 |
| Date published: | 2023-03-29 |
| Substance identifier: | |
| Substance identifier (2): | |
| Substance name: | Recombinant and non-replicating adeno-associated virus encoding the chimeric ion channel m-α7-GlyR (RP-008) |
| Additional information: | This substance is a living organism. |
| Recent publication(s): | Canada Gazette Part II, Vol. 158, No. 6, March 13 2024, SOR/2024-38 |
| Date published: | 2024-03-13 |
| Substance identifier: | |
| Substance identifier (2): | |
| Substance name: | Recombinant and non-replicating adeno-associated virus serotype 5 (AAV5) vector containing the codon-optimized coding DNA sequence for the human coagulation factor IX variant R338L (FIX-Padua) |
| Additional information: | This substance is a living organism. |
| Recent publication(s): | Canada Gazette Part II, Vol. 159, No. 6, March 12, 2025, SOR/2025-58 |
| Date published: | 2025-03-12 |